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Formerly a high-performing young marketing executive at a major consumer products company, he now shrank from the challenges of work. He just wanted to stay home and do nothing. And that very withdrawal from the active, accomplished life he once knew was an additional source of despair.

Greg had been treated with three different SSRI medications, but the symptoms kept breaking through. He was embarrassed by his feelings of hopelessness, but he couldn't control them. His wife reported that he seemed to be in a perpetual state of fatigue and overwhelming sadness-not at all like the vital, ambitious man he used to be.

Nothing seemed to interest Greg or give him joy. He couldn't concentrate on a hobby, a movie, or a book. He just sat there as life passed him by.

A recent trial of tricyclic antidepressants turned out to be another disappointment. His physician began to think of him as a likely candidate for ECT-but then he thought about Marplan's very different MAO-Inhibitor action on depression.

Greg's physician started him on 10mg of Marplan twice a day and gradually increased the dosage over a few weeks. For Greg, this was a life-changing experience. Greg had a different kind of depression-one that was treatment-resistant. He required a different kind of medication: the potent MAO-Inhibitor called Marplan.

Please see Full Prescribing Information including BOXED WARNINGS regarding increased risk of suicidality in children and adolescents. MAO-Inhibitors are contraindicated with certain drugs. Potential hypertensive crises may occur with foods that contain tyramine. As with all antidepressants, patients should be observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of treatment.