Marplan® (isocarboxazid) Tablets treatment works in a different way
The symptom-relieving action of Marplan® (isocarboxazid) Tablets is thought to involve the direct blocking effect on the enzyme monoamine oxidase. That’s why Marplan is part of a different class of antidepressant drugs called MAO inhibitors (Monoamine Oxidase Inhibitors).1
In contrast to conventional antidepressant drugs that work by raising the levels of 1 or 2 of the brain’s mood-lifting chemicals, only MAO inhibitors like Marplan are able to raise the levels of all 3 mood-lifting chemicals. Medical scientists call these mood-lifting chemicals neurotransmitters, and that’s the reason why depression is sometimes referred to as a “chemical imbalance.”3
Marplan’s different effect on brain chemistry may explain why it has been effective in the treatment of depression.1†
Isocarboxazid is a nonselective hydrazine monoamine oxidase (MAO) inhibitor. In vivo and in vitro studies demonstrated inhibition of MAO in the brain, heart, and liver. The mechanism by which MAO inhibitors act as antidepressants is not fully understood, but it is thought to involve the elevation of brain levels of biogenic amines. However, MAO is a complex enzyme system, widely distributed throughout the body, and drugs that inhibit MAO in the laboratory are associated with a number of clinical effects. Thus, it is unknown whether MAO inhibition, per se, other pharmacologic actions, or an interaction of both is responsible for the antidepressant effects observed.
† Based upon DSM-V, depression is now referred to as major depressive disorder.
Artist’s conception of effect of Marplan upon neurotransmitters.3
All patients being treated with antidepressants should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of increased or decreased dose changes.
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